Structure of PDB 6x33 Chain H Binding Site BS01

Receptor Information
>6x33 Chain H (length=3816) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
LAICCFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHAHSGMYLSCLTT
SRSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDLILVS
VSSERYLHLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLF
HGHMDECLTISPADSDDQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSH
LRWGQPLRIRHVTTGRYLALIEDQGLVVVDASKAHTKATSFCFRISKEKL
KRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDA
LSLTRCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRGSGAPAGTALP
LEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLV
LNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANC
ALFSNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSII
SLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNL
INYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWA
LTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHL
LAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGV
KVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGP
HLVGPSRCLSHTDFVPCHLERIREKLAENIHELWALTRIEQGWTYGPVRD
DNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAED
NLRKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWAR
DRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLG
YGYNIERVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVE
LGADELAYVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTIIFTL
NGEVLMSDSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSSLRFF
AICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRVDGTV
DTPPCLRLTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQEPSCV
WVGWVTPDYHQHDMNFDLTKVRAVTVTMGDNIHSSLKCSNCYMVWGGDFV
SHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQ
NVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMP
NHFLRVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDL
QQFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRA
GYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPRHGLPGVGV
TTSLRPPHHFSAPCFVAALPEAPARLSPSIPLEALRDKALRMLGEAVRDG
GQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVEE
GLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQR
DRYGILMKAFTMTAAETARRTREFRSPPQEQINMLLHFKPLPDEIRQDLL
EFHQDLLTHCGIQLQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQ
YDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENL
MIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLRFPKMVTSCCRF
LCYFCRISRQNQRSMFDHLSYLLENSGGMQGSTPLDVAAASVIDNNELAL
ALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFA
VFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLATIEEAIHLGH
AIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGII
SLPLQIPMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRA
AALALNRYLCLAVLPLITKCAPLFAMVDSMLHTVYRLSRGRSLTKAQRDV
IEECLMALCRYIRPSMLQHLLRRLVFAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAADPRPVETLNVIIPEKLDSFINKFAEYTH
EKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESL
KAMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQAMAEQLAENYHNTWG
RKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAV
TRAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAFSVLCRDLYALYPLLIRYVDNNRAHWL
TEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTED
HSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKL
DEDYLYMAYADIMAKSCHLEESFEEKEMEKQRLLYQQARLHNRGAAEMVL
QMISACKGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQ
SIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVIGEKVMADDEFTQDL
FRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFY
WYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSR
LWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGN
VVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDP
RGLISKKDFQKAAAAAAEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPR
LRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQ
VKESKRQFIFDVVNEKMELFVSFCEDTIFEMQIAAQAAAAAAAAAAAAAA
AAAEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPVYYF
LEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKL
EFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDI
YGRERIAEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAH
LLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKF
YNKMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITF
FFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDYFDT
TPHRFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWD
FFPAGDCFRKQYEDQL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6x33 Chain H Residue 5101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6x33 Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		H4976 H4981 C5025
Binding residue
(residue number reindexed from 1)		H3758 H3763 C3807
Annotation score1
Gene Ontology
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UnboundLocalError		Python 3.6.8: /usr/bin/python3
Fri Nov 29 03:56:00 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()
   1435     title=pdb2title(pdbid)
   1436     if bs.startswith("BS"):
=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)
   1438     else:
   1439         if lig3:
pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '6x33', asym_id = 'H', bs = 'BS01', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'
 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='6x33', asym_id='H', bs='BS01', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')
   1295         display_ec(ec,csaOrig,csaRenu)
   1296     if go:
=> 1297         display_go(go,uniprot,pdbid,asym_id)
   1298     return pubmed,uniprot
   1299 
global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6x33', asym_id = 'H'
 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6x33', asym_id='H')
    480         '''.replace("$namespace_link",namespace_link
    481           ).replace("$namespace",namespace
=>  482           ).replace("$uniprot",u
    483         ))
    484         for l,(term,name) in enumerate(go2aspect[Aspect]):
u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>