Structure of PDB 6x32 Chain H Binding Site BS01

Receptor Information
>6x32 Chain H (length=3798) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
LAICCFVLEQSLSVRALQEMLANTVEAGHRTLLYGHAILLRHAHSGMYLS
CLTTSRSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDL
ILVSVSSERYLHLSTLQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLF
HGHMDECLTISPADSDDQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSH
LRWGQPLRIRHVTTGRYLALIEDQGLVVVDASKAHTKATSFCFRISKEKL
KRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDA
LSLTRCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRGSGAPAGTALP
LEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLV
LNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANC
ALFSNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSII
SLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNL
INYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWA
LTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHL
LAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGV
KVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGP
HLVGPSRCLSHTDFVPCPLPPHLERIREKLAENIHELWALTRIEQGWTYG
PVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADE
KAEDNLRKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHN
VWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVR
TLLGYGYNIERVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELR
PDVELGADELAYVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTI
IFTLNGEVLMSDSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSS
LRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRV
DGTVDTPPCLRLTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQE
PSCVWVGWVTPDYHQHDMNFDLTKVRAVTVTMGDNIHSSLKCSNCYMVWG
GDFVSHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVL
PTHQNVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSW
SRMPNHFLRVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSE
RLDLQQFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPG
PLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPRRHGL
PGVGVTTSLRPPHHFSAPCFVAALPEAPARLSPSIPLEALRDKALRMLGE
AVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIE
PEVEEGLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKL
QANQRDRYGILMKAFTMTAAETARRTREFRSPPQEQINMLLHFKPLPDEI
RQDLLEFHQDLLTHCGIQLQSLQELVSHTVVRWAQEDFVQSPELVRAMFS
LLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGP
QEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGKEIRFP
KMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVA
AASVIDNNELALALQEQDLEKVVSYLAGCGLQSYPDIGWNPCGGERYLDF
LRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLATIEEAI
RISEHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVP
LDDLVGIISLPKMSASFVPDHKASMVLFLDRVYGIENAAFLLHVLDVGFL
PDMRAAATFSTTEMALALNRYLCLAVLPLITKCAPLFAMVDSMLHTVYRL
SRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFDVPAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADPRPVETLNV
IIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYK
TFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLSR
ELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARD
REKAQELLKFLQMNGYAVTRAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPLLIRYVDNNRAHW
LTEPNPSAEELFRMVGEIFIYWSKAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARRAVVACFRM
TPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEE
EVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLSFE
EKEMEKQRLLYQQARLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISI
LNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAE
GLGMVNEDGTVEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNT
TTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQ
VFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQI
ELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILK
FFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAAAAAAEFANRFQEP
ARDIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMG
ASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFV
SFCEDTIFEMQIAAQIAAAAAAAAAAAAAAAAAEVQRVKFLNYLSRNFYT
LRFLALFLAFAINFILLFYKVSDSPPVYYFLEESTGYMEPALRCLSLLHT
LVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQW
DRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAEIDVKYQIWKFGV
IFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTH
NGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKDMKCDDMMTCYLFHMYV
GVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA
FGELRDQQEQVREDMETKCFICGIGSDYFDTTPHRFETHTLEEHNLANYM
FFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6x32 Chain H Residue 5101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6x32 Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		C4956 H4976 H4981
Binding residue
(residue number reindexed from 1)		C3719 H3739 H3744
Annotation score1
Gene Ontology
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UnboundLocalError		Python 3.6.8: /usr/bin/python3
Fri Nov 29 03:53:19 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()
   1435     title=pdb2title(pdbid)
   1436     if bs.startswith("BS"):
=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)
   1438     else:
   1439         if lig3:
pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '6x32', asym_id = 'H', bs = 'BS01', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'
 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='6x32', asym_id='H', bs='BS01', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')
   1295         display_ec(ec,csaOrig,csaRenu)
   1296     if go:
=> 1297         display_go(go,uniprot,pdbid,asym_id)
   1298     return pubmed,uniprot
   1299 
global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6x32', asym_id = 'H'
 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6x32', asym_id='H')
    480         '''.replace("$namespace_link",namespace_link
    481           ).replace("$namespace",namespace
=>  482           ).replace("$uniprot",u
    483         ))
    484         for l,(term,name) in enumerate(go2aspect[Aspect]):
u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>