Structure of PDB 6waa Chain H Binding Site BS01

Receptor Information

>6waa Chain H (length=656) Species: 507522 (Klebsiella pneumoniae 342)

PALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKI
LNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSD
GLHIATLLCALFVRHFRTLVKEGHVYVALPPLYRIYYALRFKGLGEMNPM
QLRETTLDPNTRRLVQLVISDEDEQQTTAIMDMLLAKKRSEDRRNWLQEK
GDMERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSEL
GLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDG
QGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQ
EPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTT
LDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVWVITALPH
QVSGAKVLEQIAAQMRNKKLPMVSDHENPTRLMEQVMNHLFATTDLEKSY
RINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHI
LEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHL
AKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDD
RRSPLH

Ligand information

>6waa Chain O (length=13)

gatcatacaacgt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6waa Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): K444 L446 N447 S459 H498 S613 Y1018 Y1120 I1172 A1173 G1175 M1176 S1324 R1326
• Binding residue (residue number reindexed from 1): K49 L51 N52 S64 H103 S190 Y216 Y318 I370 A371 G373 M374 S499 R501

Enzymatic activity

• Enzyme Commision number: 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
• GO:0005524 ATP binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006265 DNA topological change

Cellular Component

• GO:0005694 chromosome

External links

• PDB: RCSB:6waa, PDBe:6waa, PDBj:6waa
• PDBsum: 6waa
• PubMed: 32634310
• UniProt: B5XU60