Structure of PDB 6w1n Chain H Binding Site BS01

Receptor Information
>6w1n Chain H (length=3719) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
LAICCFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHAHSGMYLSCLTT
SRSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDLILVS
VSSERYLHLSTLQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLFHGHM
DECLTISPADSDDQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHLRWG
QPLRIRHVTTGRYLALIEDQGLVVVDASKAHTKATSFCFRISKEKLKRDV
EGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDALSLT
RCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRGSGAPAGTALPLEGV
ILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCI
DRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCALFS
NNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLD
KHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYV
TSIRPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWALTEG
YSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHLLAPE
DVVSCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGVKVRF
LLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVG
PSRCLSHTDFVPCPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK
RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLR
KTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRV
AQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGY
NIRVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGAD
ELAYVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTIIFTLNGEV
LMSDSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICG
LQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRVDGTVDTPP
CLRLTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQEPSCVWVGW
VTPDYHQHDMNFDLTKVRAVTVTMGDSLKCSNCYMVWGGDFVDLVIGCLV
DLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQK
NIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLRVETRRA
GERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQQFHSHTLRLY
RAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHL
ESACRSRRSMLSEYIVPLTPETRAITLFPPRHGLPGVGVTTSLRPPHHFS
APCFVAALPEAPARLSPSIPLEALRDKALRMLGEAVRDGGQHARDPVGGS
VEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVEGLLQMKLPESVK
LQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYGILMKAFTM
TAAETARRTREFRSPPQEQINMLLHFKPLPDEIRQDLLEFHQDLLTHCGI
QLQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALP
RAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNK
VFYQHPNLMRALGMHETVMEVMVNVLGRFPKMVTSCCRFLCYFCRISRQN
QRSMFDHLSYLLENSGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLA
GCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVV
VRLLIRKPECFGPALLLATIEEGHAIMSFYAALIDLLGRCAPEMHLIQAG
KGEALRIRAILRSLVPLDDLVGIISLPKMSASFVPDHKASMVLFLDRVYG
FLLHVLDVGFLPDMRAAALALNRYLCLAVLPLITKCAPLFAMVDSMLHTV
YRLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFDVPAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADPRPVETLN
VIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPY
KTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLS
RELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKAR
DREKAQELLKFLQMNGYAVTRAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPLLIRYVDNN
RAHWLTEPNPSAEELFRMVGEIFIYWSKAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAASLRWQMALYRGAAAAAAAAAAAAAAAAAAAAAMTP
LYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEV
EEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLSFEEK
EMEKQRLLYQQARLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILN
GGNADVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGE
KVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDY
LLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGP
CTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKD
MVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIV
GSEAFQDYVTDPRGLISKKDFQKAAAAAAEEFANRFQEPARDIGFNVAVL
LTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFE
ISETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQ
IAAQEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPVYY
FLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARK
LEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGD
IYGRERIAEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAA
HLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRK
FYNKDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDI
TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDYF
DTTPHRFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERC
WDFFPAGDCFRKQYEDQLS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6w1n Chain H Residue 5101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w1n Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		C4956 H4976 H4981
Binding residue
(residue number reindexed from 1)		C3640 H3660 H3665
Annotation score1
Gene Ontology
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UnboundLocalError		Python 3.6.8: /usr/bin/python3
Sun Dec 1 17:19:18 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()
   1435     title=pdb2title(pdbid)
   1436     if bs.startswith("BS"):
=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)
   1438     else:
   1439         if lig3:
pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '6w1n', asym_id = 'H', bs = 'BS01', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'
 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='6w1n', asym_id='H', bs='BS01', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')
   1295         display_ec(ec,csaOrig,csaRenu)
   1296     if go:
=> 1297         display_go(go,uniprot,pdbid,asym_id)
   1298     return pubmed,uniprot
   1299 
global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6w1n', asym_id = 'H'
 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6w1n', asym_id='H')
    480         '''.replace("$namespace_link",namespace_link
    481           ).replace("$namespace",namespace
=>  482           ).replace("$uniprot",u
    483         ))
    484         for l,(term,name) in enumerate(go2aspect[Aspect]):
u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>