Structure of PDB 6s53 Chain H Binding Site BS01

Receptor Information
>6s53 Chain H (length=76) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGSVCPVCRQ
RFLLKNLRPNRQLANMVNNLKEISQE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6s53 Chain H Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6s53 A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C31 H33 C51 C54
Binding residue
(residue number reindexed from 1)		C26 H28 C45 C48
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6s53, PDBe:6s53, PDBj:6s53
PDBsum6s53
PubMed31582740
UniProtP19474|RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (Gene Name=TRIM21)

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