Structure of PDB 6kw5 Chain H Binding Site BS01

Receptor Information
>6kw5 Chain H (length=393) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYEQEAQKLEEKALRFLAKQTHPVIIPSFASWFDISKIHEIEKRSNPDFF
NDSSRFKTPKAYKDTRNFIINTYRLSPYEYLTITAVRRNVAMDVASIVKI
HAFLEKWGLINYQIDPRTKPSLIGPSFTGHFQVVLDTPQGLKPFLPEFPV
NLTIKKNVYDSAQDFNALQDESRNSRQIHKVYICHTCGNESINVRYHNLR
ARDTNLCSRCFQEGHFGANFQSSDFIRLENNGNSVKKNWSDQEMLLLLEG
IEMYEDQWEKIADHVGGHKRVEDCIEKFLSLPIEDNYIREVVGSKLMECV
NDAVQTLLQGDDKLGKVSDKSREISEKYIEESQAIIQELVKLTMEKLESK
FTKLCDLETQLEMEKLKYVKESEKMLNDRLSLSKQILDLNKSL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6kw5 Chain H Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6kw5 Structure of the RSC complex bound to the nucleosome
Resolution10.13 Å
Binding residue
(original residue number in PDB)		C260 C283
Binding residue
(residue number reindexed from 1)		C184 C207
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042393 histone binding
GO:0046872 metal ion binding
Biological Process
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006325 chromatin organization
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006368 transcription elongation by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0016586 RSC-type complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kw5, PDBe:6kw5, PDBj:6kw5
PDBsum6kw5
PubMed
UniProtP43609|RSC8_YEAST Chromatin structure-remodeling complex protein RSC8 (Gene Name=RSC8)

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