Structure of PDB 6jpw Chain H Binding Site BS01

Receptor Information
>6jpw Chain H (length=154) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAIT
QGKR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6jpw Biocompatible Macrocyclization between Cysteine and 2-Cyanopyridine Generates Stable Peptide Inhibitors.
Resolution1.951 Å
Binding residue
(original residue number in PDB)		H51 D129 Y130 A132 G133 S135 G151 N152 G153 V154 V155 Y161
Binding residue
(residue number reindexed from 1)		H35 D113 Y114 A116 G117 S119 G135 N136 G137 V138 V139 Y145
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6jpw, PDBe:6jpw, PDBj:6jpw
PDBsum6jpw
PubMed31188009
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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