Structure of PDB 6hrm Chain H Binding Site BS01

Receptor Information
>6hrm Chain H (length=130) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVY
MRVVRNTLLRRAVEGTPFECLKDAFVGPTLIAYSMEHPGAAARLFKEFAK
ANAKFEVKAAAFEGELIPASQIDRLATLPT
Ligand information
>6hrm Chain 1 (length=4450) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacg
aguggcggacgggugaguaaugucugggaaacugccugauggagggggau
aacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagag
ggggaccuucgggccucuugccaucggaugugcccagaugggauuagcua
guaggugggguaacggcucaccuaggcgacgaucccuagcuggucugaga
ggaugaccagccacacuggaacugagacacgguccagacuccuacgggag
gcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugc
cgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggagg
aagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaag
caccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcg
uuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaaguca
gaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaag
cuugagucucguagagggggguagaauuccagguguagcggugaaaugcg
uagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagac
ugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugg
uaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcgu
ggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgca
agguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcau
gugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacaucca
cggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggug
cugcauggcugucgucagcucguguugugaaauguuggguuaagucccgc
aacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacuca
aaggagacugccagugauaaacuggaggaagguggggaugacgucaaguc
aucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauaca
aagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguag
uccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaa
ucguggaucagaaugccacggugaauacguucccgggccuuguacacacc
gcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccg
gucaacagccguuugagcuaaccgguacuaaugaaccgugaggcuuaacc
uugagagguuaagcgacuaagcguacacgguggaugcccuggcagucaga
ggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauauga
accguuauaaccggcgauuuccgaauggggaaacccaguguguuucgaca
cacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacug
aaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccagua
gcggcgagcgaacggggagcagcccagagccugaaucaguguguguguua
guggaagcgucuggaaaggcgcgcgauacagggugacagccccguacaca
aaaaugcacaugcugugagcucgaugaguagggcgggacacgugguaucc
ugucugaauauggggggaccauccuccaaggcuaaauacuccugacugac
cgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgagg
ggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgc
uuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauu
cuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaa
cugggcguuaaguugcaggguauagacccgaaacccggugaucuagccau
gggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaau
guugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaa
ccgggagauagcugguucuccccgaaagcuauuuagguagcgccucguga
auucaucuccggggguagagcacuguuucggcaagggggucaucccgacu
uaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagac
acacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgc
cagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcc
cagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcgu
aauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaa
ccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguagggga
gcguucuguaagccugcgaaggugugcugugaggcaugcuggagguauca
gaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcu
cgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagu
cgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaau
auuccuguacuugguguuacugcgaaggggggacggagaaggcuauguug
gccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggca
aauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcuga
agcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacau
caaaucguaccccaaaccgacacagguggucagguagagaauaccaaggc
gcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuuc
gggagaaggcacgcugauauguaggugaggucccucgcggauggagcuga
aaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagca
cugugcaaacacgaaaguggacguauacggugugacgccugcccggugcc
ggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccc
cgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuu
gucggguaaguuccgaccugcacgaauggcguaaugauggccaggcuguc
uccacccgagacucagugaaauugaacucgcugugaagaugcaguguacc
cgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacuga
acauugagccuugauguguaggauaggugggaggcuuugaaguguggacg
ccagucugcauggagccgaccuugaaauaccacccuuuaauguuugaugu
ucuaacguugacccguaauccggguugcggacagugucugguggguaguu
ugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguugg
cuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuu
gacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauc
cggugguucugaauggaagggccaucgcucaacggauaaaagguacuccg
gggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuug
gcaccucgaugucggcucaucacauccuggggcugaaguaggucccaagg
guauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacguc
gugagacaguucggucccuaucugccgugggcgcuggagaacugaggggg
gcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggg
uugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagug
cugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacc
cuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggg
uguguaaacggacaugguuggagggcgcuuaccacuuugugauucaugac
uggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca
........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<......<<<<<<......>>>>>>.....>.
.>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<...
..<<<<<......>>>>>......>>.>.....<<<....>>>....<<<
<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<.
.<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....
>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>
...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>
>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<....
..<<<<<<<<.<........>>>>>>>.>>.......>>>>>....>..<
<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>
>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<
<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>
>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>.
.....>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>
>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>.
..>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>
>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<...
.>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<
<<<<<......<<........>>..........<<<<<<<......<<..
<<<..<<<<<<<....>>>>>>>...<......>..>>>...>>.<<<.<
<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>.
.>>>>>>.....<<<<.<<<<<<<...<<..<<.......>>>>....>>
>>>>>.....<<<<<.....>>>>>........>>>>.........>>>.
..>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<...
..<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>....
..<....<<<<<<<........>>>>>>>....>.....>>>>>>....<
<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....
<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<.
........<<<.....<<...<<<<<.<<<.....<<..<..<<<<<<<<
<....>>>>>>>>>......<<<<<<<<<<<.....[[..[[<<<<<<<[
[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....
>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>
>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<
<....>>......>>>>>.>.........<<....>>..<<<<<<.....
<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.
<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>.
..>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>
>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]
]...............<<....>>....]].........<<<<.....>>
>>..................>>>>>>>>>>>.......<<<<..<<<<<<
....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<
<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<...
..>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<
<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<
........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>
>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<
...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>
..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>..
.<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<
.<<<...<<<(((.....<<<<<<...........<<..<<<.....<..
......<<<<<.<<...<<...........>>...>>........<<<..
....>>>..>>>>>....>.....>>>.>>...........))).....>
>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>
><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>
>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>>
<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((
<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<.....
...>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<
<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<..
...>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>..
.>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>
>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>
>..<<<<....<<<<<<<<.<<...............<<<<<....<<..
>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>..
.>>>>>>............<<<<<<<<<..<<<.........>>>..<<<
<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<
<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>
>>>>..>>>>><<<<<<.......>>>>>>........<...........
<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>
>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<
<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<
<<<<...<<..<<<...........<<<<<..<<<......<<..<<<<.
...>>>>..>>...>>>............>>>>>..>>>..>.>..>>>>
>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>.
.<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>.
..<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......
<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>
>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>
>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>
>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<.
.<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<
<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<
<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<
<.....>>>>>>....>>..<<<<<.......>>>>>....>>>>>>>>.
.>>.....>>>........>>.>>>>>>>>>>...>>>>>>>>>>>>..>
>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hrm Controlling orthogonal ribosome subunit interactions enables evolution of new function.
Resolution2.96 Å
Binding residue
(original residue number in PDB)
A2 N4 K8 I11 S30 R31 G32 V33 T34 M38 L41 V54 V55 R56 T58 L59 L60 R61 R62 E65 P79 L81
Binding residue
(residue number reindexed from 1)
A1 N3 K7 I10 S29 R30 G31 V32 T33 M37 L40 V53 V54 R55 T57 L58 L59 R60 R61 E64 P78 L80
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0015934 large ribosomal subunit

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6hrm, PDBe:6hrm, PDBj:6hrm
PDBsum6hrm
PubMed30518861
UniProtP0A7J3|RL10_ECOLI Large ribosomal subunit protein uL10 (Gene Name=rplJ)

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