Structure of PDB 6gn7 Chain H Binding Site BS01

Receptor Information
>6gn7 Chain H (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gn7 Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		I24 R75 Y76 E77 R77A N78 I79 Y117
Binding residue
(residue number reindexed from 1)		I9 R70 Y71 E72 R73 N74 I75 Y114
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6gn7, PDBe:6gn7, PDBj:6gn7
PDBsum6gn7
PubMed30357392
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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