Structure of PDB 6exn Chain H Binding Site BS01

Receptor Information
>6exn Chain H (length=411) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKFQRENWEMIRSHVSPIISNLTMDNLQESHRDLFQVNILIGRNIICKNV
VDFTLNNGRLIPALSALIALLNSDIPDIGETLAKELMLMFVQQFNRKDYV
SCGNILQCLSILFLYDVIHEIVILQILLLLLEKNSLRLVIAVMKICGWKL
ALVSKKTHDMIWEKLRYILQTQELSSTLRESLETLFEIRQKDYKSCENFN
ELTMAFDTLRQKLDVEFKKKIYLVLKSSLSGDEAAHKLLKLKIANNLKKS
VVDIIIKSSLQESTFSKFYSILSERMITFHRSWQTAYNETFEQNYTQDIE
DYETDQLRILGKFWGHLISYEFLPMDCLKIIKLTEEESCPQGRIFIKFLF
QELVNELGLDELQLRLNSSKLDGMFPLEGDAEHIRYSINFFTAIGLGLTE
DMRSRLTIIQE
Ligand information
>6exn Chain E (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agugaucuagaaagagauccaccuacucaugu
................................
Receptor-Ligand Complex Structure
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PDB6exn Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		K317 F354 H355
Binding residue
(residue number reindexed from 1)		K242 F279 H280
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003723 RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005737 cytoplasm
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6exn, PDBe:6exn, PDBj:6exn
PDBsum6exn
PubMed29146871
UniProtP53333|CWC22_YEAST Pre-mRNA-splicing factor CWC22 (Gene Name=CWC22)

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