Structure of PDB 6eo7 Chain H Binding Site BS01

Receptor Information
>6eo7 Chain H (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6eo7 Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Resolution2.24 Å
Binding residue
(original residue number in PDB)		I372 R433 Y434 E435 R436 N437 I438 I441 Y477
Binding residue
(residue number reindexed from 1)		I9 R70 Y71 E72 R73 N74 I75 I78 Y114
Binding affinityPDBbind-CN: Kd=0.39nM
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6eo7, PDBe:6eo7, PDBj:6eo7
PDBsum6eo7
PubMed29684204
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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