Structure of PDB 6d6r Chain H Binding Site BS01

Receptor Information
>6d6r Chain H (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEE
KLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVET
NSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFS
DGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNN
GFIWIYPTPEHKGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDT
SILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG
Ligand information
>6d6r Chain O (length=48) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tctttacggtgctcaccacaccacacacaccacaccacacaaaaaaaa
................................................
Receptor-Ligand Complex Structure
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PDB6d6r Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		K94 R95 F149 S150 D151
Binding residue
(residue number reindexed from 1)		K94 R95 F149 S150 D151
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003723 RNA binding
GO:0004532 RNA exonuclease activity
GO:0005515 protein binding
GO:0008312 7S RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006401 RNA catabolic process
GO:0030307 positive regulation of cell growth
GO:0034475 U4 snRNA 3'-end processing
GO:0071034 CUT catabolic process
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 TRAMP-dependent tRNA surveillance pathway
GO:0071051 poly(A)-dependent snoRNA 3'-end processing
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0101019 nucleolar exosome (RNase complex)

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6d6r, PDBe:6d6r, PDBj:6d6r
PDBsum6d6r
PubMed29906447
UniProtQ13868|EXOS2_HUMAN Exosome complex component RRP4 (Gene Name=EXOSC2)

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