Structure of PDB 6crd Chain H Binding Site BS01

Receptor Information
>6crd Chain H (length=435) Species: 2280,384509 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INETADDIVYRLTVIIDDRYESLKNLITLRADRLEMIINDNVSTILARDF
NNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYAL
SQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSC
HDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCH
NGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSCYGE
RAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPNDPTV
GKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPNALT
DDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKE
DKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL
Ligand information
Ligand IDBMA
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-RWOPYEJCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-mannopyranose;
beta-D-mannose;
D-mannose;
mannose
ChEMBL
DrugBank
ZINCZINC000003830679
PDB chain6crd Chain T Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6crd Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion-domain stalk.
Resolution2.57 Å
Binding residue
(original residue number in PDB)		P390 Q392
Binding residue
(residue number reindexed from 1)		P356 Q358
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6crd, PDBe:6crd, PDBj:6crd
PDBsum6crd
PubMed30713159
UniProtP03472|NRAM_I75A5 Neuraminidase (Gene Name=NA);
Q54436

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