Structure of PDB 6baa Chain H Binding Site BS01

Receptor Information
>6baa Chain H (length=1317) Species: 10034 (Cricetus cricetus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQS
SKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLH
LYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFV
KFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVK
PPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIAKLPI
AMRALTNYQRLCVAFDAARAIWRALCHAFGRRLILSSTFRILADLLGFAG
PLCIFGIVDHLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAI
QTKIYNKIMHMSAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVIL
LYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTNE
MLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIP
IAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTV
KALVSVQKLSEFLSCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVG
QVGCGKSSLLLATLGEMQKVSGAVFWNSNLPVAYASQKPWLLNATVEENI
TFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRI
SVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVT
HKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWACTKYLSSAG
ILLLSLLVFSQLLKHMVLVAIDYWLAKWTDYAMVFTLLCSLGIVLCLVTS
VTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTID
QHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFR
VASRDLQQLDDTTQLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDS
NNIASLFLTAANRWLEVCMEYIGACVVLIAAATSISNSLSAGLVGLGLTY
ALMVSNYLNWMVRNLADMEIQLGAVKRIHALLGKIQIQNLSVRYDSSLKP
VLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDI
AKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQL
KLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATA
SIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEF
DKPETLLSQKDSVFASF
Ligand information
Ligand IDGBM
InChIInChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
InChIKeyZNNLBTZKUZBEKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(NC1CCCCC1)NS(=O)(=O)c3ccc(CCNC(=O)c2c(OC)ccc(Cl)c2)cc3
CACTVS 3.385COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)[S](=O)(=O)NC(=O)NC3CCCCC3
OpenEye OEToolkits 1.9.2COc1ccc(cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3)Cl
FormulaC23 H28 Cl N3 O5 S
Name5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide;
Glibenclamide;
Glyburide
ChEMBLCHEMBL472
DrugBankDB01016
ZINCZINC000000537805
PDB chain6baa Chain H Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6baa Anti-diabetic drug binding site in a mammalian KATPchannel revealed by Cryo-EM.
Resolution3.63 Å
Binding residue
(original residue number in PDB)		Y377 F433 N437 L592 S1238 T1242 N1245 R1246
Binding residue
(residue number reindexed from 1)		Y336 F382 N386 L541 S1005 T1009 N1012 R1013
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6baa, PDBe:6baa, PDBj:6baa
PDBsum6baa
PubMed29035201
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

[Back to BioLiP]