Structure of PDB 5h9e Chain H Binding Site BS01

Receptor Information
>5h9e Chain H (length=352) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKS
GYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKSVD
EAEKISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIR
VNLQQGVDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFT
AVDDLQEQGSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIA
THVVHMLATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAK
DGFLQPSIQAFNQYWDRVANGYGLNGAAAQFSLSVKQMPTLEQLKSWVRN
NG
Ligand information
>5h9e Chain L (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auaaaccgacgguauuguucagauccuggcuugccaacaggaguuccccg
cgccagcgggg
..............................................<<<<
<....>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5h9e Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
Resolution3.21 Å
Binding residue
(original residue number in PDB)		N19 R20 D21 D22 K27 S40 Q42 S43 K45 R46 R49 M166 K177 W199 F200 T201 A202 V203 A265
Binding residue
(residue number reindexed from 1)		N18 R19 D20 D21 K26 S39 Q41 S42 K44 R45 R48 M165 K176 W198 F199 T200 A201 V202 A264
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5h9e, PDBe:5h9e, PDBj:5h9e
PDBsum5h9e
PubMed26863189
UniProtQ46899|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

[Back to BioLiP]