Structure of PDB 5gds Chain H Binding Site BS01

Receptor Information
>5gds Chain H (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FGE
Ligand information
Receptor-Ligand Complex Structure
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PDB5gds Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		K36 Q38 H57 Y60A R73 T74 R75 Y76 I174 W215 G216 E217 G219 C220
Binding residue
(residue number reindexed from 1)		K21 Q24 H43 Y47 R68 T69 R70 Y71 I173 W221 G222 E223 G224 C225
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5gds, PDBe:5gds, PDBj:5gds
PDBsum5gds
PubMed9521099
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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