Structure of PDB 5do4 Chain H Binding Site BS01

Receptor Information
>5do4 Chain H (length=256) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETANV
GKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACE
GDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK
VIDQFG
Ligand information
>5do4 Chain A (length=25) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggaacaaagcugaaguacuuaccc
<<<....<<<........>>>.>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5do4 Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
Resolution1.859 Å
Binding residue
(original residue number in PDB)		H87 P88 R89 R98 R123 E169 R170 P171 D183 N184 R245 L246 K248 W249
Binding residue
(residue number reindexed from 1)		H87 P88 R89 R98 R123 E167 R168 P169 D181 N182 R243 L244 K246 W247
Binding affinityPDBbind-CN: Kd=1.8pM
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5do4, PDBe:5do4, PDBj:5do4
PDBsum5do4
PubMed27566147
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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