Structure of PDB 5cmx Chain H Binding Site BS01

Receptor Information
>5cmx Chain H (length=249) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
Ligand information
>5cmx Chain L (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB5cmx Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding.
Resolution2.98 Å
Binding residue
(original residue number in PDB)		E23 I24 G25 M26 P28 W29 D116 H119 C122 Y134 K135 G136 R137 N159 K202 R206 W207
Binding residue
(residue number reindexed from 1)		E8 I9 G10 M11 P13 W14 D113 H116 C119 Y134 K135 G136 R137 N157 K205 R211 W212
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5cmx, PDBe:5cmx, PDBj:5cmx
PDBsum5cmx
PubMed26673709
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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