Structure of PDB 5a2m Chain H Binding Site BS01
Receptor Information
>5a2m Chain H (length=250) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
>5a2m Chain I (length=10) Species:
6421
(Hirudo medicinalis) [
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DFEEIPEEYL
Receptor-Ligand Complex Structure
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PDB
5a2m
Thrombin Inhibition
Resolution
1.4 Å
Binding residue
(original residue number in PDB)
F34 L40 L65 T74 R75 Y76 K81 I82 F245
Binding residue
(residue number reindexed from 1)
F19 L26 L60 T69 R70 Y71 K77 I78 F250
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:5a2m
,
PDBe:5a2m
,
PDBj:5a2m
PDBsum
5a2m
PubMed
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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