Structure of PDB 4udw Chain H Binding Site BS01
Receptor Information
>4udw Chain H (length=251) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
>4udw Chain I (length=11) Species:
6421
(Hirudo medicinalis) [
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DFEEIPEEYLQ
Receptor-Ligand Complex Structure
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PDB
4udw
Fragments Can Bind Either More Enthalpy or Entropy-Driven: Crystal Structures and Residual Hydration Pattern Suggest Why.
Resolution
1.16 Å
Binding residue
(original residue number in PDB)
F34 L65 R73 T74 R75 Y76 K81 I82
Binding residue
(residue number reindexed from 1)
F19 L60 R68 T69 R70 Y71 K77 I78
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:4udw
,
PDBe:4udw
,
PDBj:4udw
PDBsum
4udw
PubMed
26270568
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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