Structure of PDB 4ud9 Chain H Binding Site BS01

Receptor Information
>4ud9 Chain H (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQFG
Ligand information
Receptor-Ligand Complex Structure
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PDB4ud9 Fragments Can Bind Either More Enthalpy or Entropy-Driven: Crystal Structures and Residual Hydration Pattern Suggest Why.
Resolution1.124 Å
Binding residue
(original residue number in PDB)		F34 L40 L65 R67 R73 T74 R75 Y76 K81 I82 G246
Binding residue
(residue number reindexed from 1)		F19 L26 L60 R62 R68 T69 R70 Y71 K77 I78 G254
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ud9, PDBe:4ud9, PDBj:4ud9
PDBsum4ud9
PubMed26270568
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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