Structure of PDB 4nqa Chain H Binding Site BS01

Receptor Information
>4nqa Chain H (length=319) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD
CLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSA
NEDMPVERILEAELAVEPKTETNDPVTNICQAADKQLFTLVEWAKRIPHF
SELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHS
AGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEV
EALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFF
KLIGDTPIDTFLMEMLEAP
Ligand information
Receptor-Ligand Complex Structure
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PDB4nqa Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA.
Resolution3.102 Å
Binding residue
(original residue number in PDB)		F277 V280 K284 L294 V298 L301 F450 E453
Binding residue
(residue number reindexed from 1)		F138 V141 K145 L155 V159 L162 F311 E314
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nqa, PDBe:4nqa, PDBj:4nqa
PDBsum4nqa
PubMed24561505
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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