Structure of PDB 4e06 Chain H Binding Site BS01

Receptor Information
>4e06 Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
Ligand information
>4e06 Chain L (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYID
Receptor-Ligand Complex Structure
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PDB4e06 Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.
Resolution3.196 Å
Binding residue
(original residue number in PDB)		E328 G330 M331 P333 W334 D433 H436 C439 L449 Y454 K455 R457 N484 K516 K532 N537 R538 W539
Binding residue
(residue number reindexed from 1)		E8 G10 M11 P13 W14 D113 H116 C119 L129 Y134 K135 R137 N157 K189 K205 N210 R211 W212
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4e06, PDBe:4e06, PDBj:4e06
PDBsum4e06
PubMed23223529
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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