Structure of PDB 4d4p Chain H Binding Site BS01

Receptor Information
>4d4p Chain H (length=74) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMSTYDEIEIEDMTFEPENQMFTYPCPCGDRFQIYLDDMFEEKVAVCPSC
SLMIDVVFDKEDLAEYYEEAGIHP
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain4d4p Chain H Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4d4p Structure of the Kti11/Kti13 Heterodimer and its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2.
Resolution2.999 Å
Binding residue
(original residue number in PDB)		C368 C370 C390 C393
Binding residue
(residue number reindexed from 1)		C26 C28 C47 C50
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors
GO:0034986 iron chaperone activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008033 tRNA processing
GO:0016567 protein ubiquitination
GO:0017183 protein histidyl modification to diphthamide
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4d4p, PDBe:4d4p, PDBj:4d4p
PDBsum4d4p
PubMed25543256
UniProtP31386|ATS1_YEAST Protein KTI13 (Gene Name=ATS1);
Q3E840|DPH3_YEAST Diphthamide biosynthesis protein 3 (Gene Name=KTI11)

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