Structure of PDB 4ch8 Chain H Binding Site BS01

Receptor Information
>4ch8 Chain H (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
>4ch8 Chain G (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DCGLRPLFEKKSLEDKTERELLESYID
Receptor-Ligand Complex Structure
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PDB4ch8 Gpibalpha Interacts Exclusively with Exosite II of Thrombin
Resolution1.75 Å
Binding residue
(original residue number in PDB)		E328 G330 M331 P333 W334 D433 H436 P437 C439 Y454 K455 G456 R457 N484 K532 P534 N537 R538 W539
Binding residue
(residue number reindexed from 1)		E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 G136 R137 N164 K212 P214 N217 R218 W219
Enzymatic activity
Catalytic site (original residue number in PDB) H363 D419 E522 G523 D524 S525 G526
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ch8, PDBe:4ch8, PDBj:4ch8
PDBsum4ch8
PubMed24316004
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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