Structure of PDB 4boh Chain H Binding Site BS01

Receptor Information
>4boh Chain H (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDAC
EGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ
KVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4boh The Tick-Derived Anticoagulant Madanin is Processed by Thrombin and Factor Xa.
Resolution2.595 Å
Binding residue
(original residue number in PDB)		H363 Y367 N415 L416 N471 I499 D519 A520 C521 W547 G548
Binding residue
(residue number reindexed from 1)		H43 Y47 N95 L96 N151 I178 D198 A199 C200 W226 G227
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4boh, PDBe:4boh, PDBj:4boh
PDBsum4boh
PubMed23951260
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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