Structure of PDB 3iyd Chain H Binding Site BS01

Receptor Information
>3iyd Chain H (length=201) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKE
MILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQV
NPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMT
HPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT
R
Ligand information
>3iyd Chain I (length=98) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcaataaatgtgatctagatcacattttaggcaaaaaaggctttacact
ttatgcttccggctcgtataatcgcaccttatgtgagcggataacaag
Receptor-Ligand Complex Structure
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PDB3iyd Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Resolution19.8 Å
Binding residue
(original residue number in PDB)		E58 T168 R169 Q170 K188
Binding residue
(residue number reindexed from 1)		E50 T160 R161 Q162 K180
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0030552 cAMP binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0045013 carbon catabolite repression of transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol
GO:0032993 protein-DNA complex

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Cellular Component
External links
PDB RCSB:3iyd, PDBe:3iyd, PDBj:3iyd
PDBsum3iyd
PubMed19903881
UniProtP0ACJ8|CRP_ECOLI DNA-binding transcriptional dual regulator CRP (Gene Name=crp)

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