Structure of PDB 2zhw Chain H Binding Site BS01

Receptor Information
>2zhw Chain H (length=249) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
>2zhw Chain L (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB2zhw Exploring thrombin S3 pocket
Resolution2.02 Å
Binding residue
(original residue number in PDB)		E23 I24 M26 P28 W29 D116 H119 C122 Y134 K135 G136 R137 N159 M201 K202 R206 W207
Binding residue
(residue number reindexed from 1)		E8 I9 M11 P13 W14 D113 H116 C119 Y134 K135 G136 R137 N156 M203 K204 R210 W211
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2zhw, PDBe:2zhw, PDBj:2zhw
PDBsum2zhw
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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