Structure of PDB 2xwb Chain H Binding Site BS01

Receptor Information
>2xwb Chain H (length=711) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWST
LKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDG
YTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLE
DSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAF
LSSLTETIEGVDAEDDPSGSMNIYLVLDGSGSIGASDFTGAKKCLVNLIE
KVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHK
LKSGTNTKKALQAVYSMMSWPWNRTRHVIILMTDGLHNMGGDPITVIDEI
RDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKV
KDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPS
KGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLF
HPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTR
ALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGS
CERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIV
HKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEK
LQDEDLGFLAA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2xwb Chain H Residue 1742 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2xwb Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Resolution3.49 Å
Binding residue
(original residue number in PDB)		S253 S255 T328
Binding residue
(residue number reindexed from 1)		S230 S232 T305
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) G672 S674 G675
Catalytic site (residue number reindexed from 1) G642 S644 G645
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Gene Ontology
Molecular Function
GO:0001848 complement binding
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0009617 response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2xwb, PDBe:2xwb, PDBj:2xwb
PDBsum2xwb
PubMed21205667
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

[Back to BioLiP]