Structure of PDB 2irf Chain H Binding Site BS01

Receptor Information

>2irf Chain H (length=109) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPL
FRNWAIHTGKHQPGIDKPDPKTWKANFRCAMNSLPDIEEVKDRSIKKGNN
AFRVYRMLP

Ligand information

>2irf Chain A (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aagtgaaaguga

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2irf Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	W238 H240 A241 K275 K278 R282
Binding residue (residue number reindexed from 1)	W34 H36 A37 K71 K74 R78
Binding affinity	PDBbind-CN: Kd=0.17uM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:2irf, PDBe:2irf, PDBj:2irf
PDBsum	2irf
PubMed	10487755
UniProt	P23906\|IRF2_MOUSE Interferon regulatory factor 2 (Gene Name=Irf2)

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