Structure of PDB 2hgt Chain H Binding Site BS01

Receptor Information
>2hgt Chain H (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2hgt Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H57 Y60A L99 D189 A190 E192 G193 S195 W215 G216
Binding residue
(residue number reindexed from 1)		H43 Y47 L96 D193 A194 E196 G197 S199 W221 G222
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2hgt, PDBe:2hgt, PDBj:2hgt
PDBsum2hgt
PubMed1942057
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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