Structure of PDB 2gde Chain H Binding Site BS01
Receptor Information
>2gde Chain H (length=249) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
Ligand information
>2gde Chain L (length=27) Species:
9606
(Homo sapiens) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
2gde
Total synthesis and structural confirmation of chlorodysinosin A.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
E23 I24 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 G136 R137 N159 K202 P204 N205 R206 W207
Binding residue
(residue number reindexed from 1)
E8 I9 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 G136 R137 N157 K205 P207 N210 R211 W212
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:2gde
,
PDBe:2gde
,
PDBj:2gde
PDBsum
2gde
PubMed
16895415
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
[
Back to BioLiP
]