Structure of PDB 2bxu Chain H Binding Site BS01

Receptor Information
>2bxu Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
Ligand information
Receptor-Ligand Complex Structure
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PDB2bxu Design and Discovery of Novel, Potent Pyrazinone-Based Thrombin Inhibitors with a Solubilizing P1-P2-Linker
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Q38 L40 R67 R73 T74 R75 Y76 K81 I82 F245
Binding residue
(residue number reindexed from 1)		Q24 L26 R62 R68 T69 R70 Y71 K77 I78 F251
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2bxu, PDBe:2bxu, PDBj:2bxu
PDBsum2bxu
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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