Structure of PDB 2ank Chain H Binding Site BS01

Receptor Information
>2ank Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB2ank Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety
Resolution2.46 Å
Binding residue
(original residue number in PDB)		K36 Q38 L40 N62 L65 R73 T74 Y76 K81 I82 M84
Binding residue
(residue number reindexed from 1)		K21 Q24 L26 N57 L60 R68 T69 Y71 K77 I78 M80
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2ank, PDBe:2ank, PDBj:2ank
PDBsum2ank
PubMed16460939
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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