Structure of PDB 2aep Chain H Binding Site BS01

Receptor Information

>2aep Chain H (length=143) Species: 10090 (Mus musculus)

EVKLVESGGGLVQPGGSLSLSCATSGFTFIDYYMSWFRQPPGKALEWLGL
IRNKGNGYTMEYSASLKGRFTISRDNSQSIVYLHMNTLTAEDSATYYCAR
VDYGTNYDYWGQGTTLTVSSAKTFPEPVTLTGVHTFPATLSSS

Ligand information

• Ligand ID: GLC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-glucopyranose;
  alpha-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL423707
• ZINC: ZINC000003861213
• PDB chain: 2aep Chain H Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2aep An Epidemiologically Significant Epitope of a 1998 Human Influenza Virus Neuraminidase Forms a Highly Hydrated Interface in the NA-Antibody Complex
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): D96 N100 D101
• Binding residue (residue number reindexed from 1): D102 N106 D108
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003823 antigen binding

Biological Process

• GO:0002250 adaptive immune response
• GO:0016064 immunoglobulin mediated immune response

Cellular Component

• GO:0005576 extracellular region
• GO:0019814 immunoglobulin complex

External links

• PDB: RCSB:2aep, PDBe:2aep, PDBj:2aep
• PDBsum: 2aep
• PubMed: 16384583
• UniProt: P84751|HVM63_MOUSE Ig heavy chain Mem5 (Fragment)