Structure of PDB 1ypg Chain H Binding Site BS01

Receptor Information
>1ypg Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
Ligand information
>1ypg Chain L (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB1ypg A simple protocol to estimate differences in protein binding affinity for enantiomers without prior resolution of racemates
Resolution1.8 Å
Binding residue
(original residue number in PDB)		E23 I24 G25 M26 W29 H119 P120 C122 Y134 K135 R137 N159 M201 K202 R206 W207
Binding residue
(residue number reindexed from 1)		E8 I9 G10 M11 W14 H116 P117 C119 Y134 K135 R137 N158 M205 K206 R212 W213
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ypg, PDBe:1ypg, PDBj:1ypg
PDBsum1ypg
PubMed16374786
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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