Structure of PDB 1ycp Chain H Binding Site BS01

Receptor Information
>1ycp Chain H (length=247) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDI
ALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRREVQPS
VLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGP
FVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
Ligand information
>1ycp Chain L (length=29) Species: 9913 (Bos taurus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKQVQDQTEKELFESYIEG
Receptor-Ligand Complex Structure
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PDB1ycp Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E23 G25 L26 W29 D116 Y117 H119 C122 F134 K135 R137 N159 K202 P204 N205 R206 W207
Binding residue
(residue number reindexed from 1)		E8 G10 L11 W14 D113 Y114 H116 C119 F134 K135 R137 N156 K204 P206 N209 R210 W211
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ycp, PDBe:1ycp, PDBj:1ycp
PDBsum1ycp
PubMed9307032
UniProtP00735|THRB_BOVIN Prothrombin (Gene Name=F2)

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