Structure of PDB 1xk4 Chain H Binding Site BS01

PDB	1xk4 The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins
Resolution	1.8 Å
Binding residue (original residue number in PDB)	D67 N69 D71 Q73 E78
Binding residue (residue number reindexed from 1)	D64 N66 D68 Q70 E75
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0016209	antioxidant activity
GO:0035662	Toll-like receptor 4 binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0050544	arachidonate binding
GO:0050786	RAGE receptor binding

	Biological Process
GO:0002523	leukocyte migration involved in inflammatory response
GO:0002544	chronic inflammatory response
GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007267	cell-cell signaling
GO:0010976	positive regulation of neuron projection development
GO:0014002	astrocyte development
GO:0030307	positive regulation of cell growth
GO:0030593	neutrophil chemotaxis
GO:0032119	sequestering of zinc ion
GO:0032496	response to lipopolysaccharide
GO:0034121	regulation of toll-like receptor signaling pathway
GO:0035425	autocrine signaling
GO:0035606	peptidyl-cysteine S-trans-nitrosylation
GO:0035821	modulation of process of another organism
GO:0042742	defense response to bacterium
GO:0043542	endothelial cell migration
GO:0045087	innate immune response
GO:0045113	regulation of integrin biosynthetic process
GO:0050729	positive regulation of inflammatory response
GO:0050832	defense response to fungus
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051493	regulation of cytoskeleton organization
GO:0060264	regulation of respiratory burst involved in inflammatory response
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070488	neutrophil aggregation
GO:0098869	cellular oxidant detoxification
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0034774	secretory granule lumen
GO:0062023	collagen-containing extracellular matrix
GO:0070062	extracellular exosome
GO:1990660	calprotectin complex
GO:1990662	S100A9 complex

External links

PDB	RCSB:1xk4, PDBe:1xk4, PDBj:1xk4
PDBsum	1xk4
PubMed	17553524
UniProt	P06702\|S10A9_HUMAN Protein S100-A9 (Gene Name=S100A9)