Structure of PDB 1w7g Chain H Binding Site BS01

Receptor Information
>1w7g Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FG
Ligand information
Receptor-Ligand Complex Structure
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PDB1w7g Design, Synthesis and Evaluation of Graftable Thrombin Inhibitors for the Preparation of Blood-Compatible Polymer Materials.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		F34 E39 L40 R73 T74 R75 Y76 I82 F245 G246
Binding residue
(residue number reindexed from 1)		F19 E25 L26 R68 T69 R70 Y71 I78 F251 G252
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1w7g, PDBe:1w7g, PDBj:1w7g
PDBsum1w7g
PubMed16294249
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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