Structure of PDB 1w0m Chain H Binding Site BS01

Receptor Information

>1w0m Chain H (length=225) Species: 2271 (Thermoproteus tenax)

MRLPILIINFKAYGEAAGKRAVELAKAAERAARELGVNIVVAPNHLELGL
VSQSVDIPVYAQGADVEAGGAHTAHVSLENIKEAGGSGVILNHSEAPLKL
NDLARLVAKAKSLGLDVVVCAPDPRTSLAAAALGPHAVAVEPPELIGTGR
AVSRYKPEAIVETVGLVSRHFPEVSVITGAGIESGDDVAAALRLGTRGVL
LASAAVKAKDPYAKIVELAKPLSEL

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1w0m Chain H Residue 1226

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1w0m Structure and Function of a Regulated Archaeal Triosephosphate Isomerase Adapted to High Temperature
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): I146 G147 L201 A202 S203
• Binding residue (residue number reindexed from 1): I146 G147 L201 A202 S203
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.1: triose-phosphate isomerase.

Gene Ontology

Molecular Function

• GO:0004807 triose-phosphate isomerase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0006094 gluconeogenesis
• GO:0006096 glycolytic process
• GO:0019563 glycerol catabolic process
• GO:0046166 glyceraldehyde-3-phosphate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1w0m, PDBe:1w0m, PDBj:1w0m
• PDBsum: 1w0m
• PubMed: 15342242
• UniProt: Q8NKN9|TPIS_THETK Triosephosphate isomerase (Gene Name=tpiA)