Structure of PDB 1vzq Chain H Binding Site BS01

Receptor Information
>1vzq Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTAYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB1vzq Stable Expression and Purification of a Secreted Human Recombinant Prethrombin-2 and its Activation to Thrombin
Resolution1.54 Å
Binding residue
(original residue number in PDB)		F34 R73 T74 Y76
Binding residue
(residue number reindexed from 1)		F19 R68 T69 Y71
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1vzq, PDBe:1vzq, PDBj:1vzq
PDBsum1vzq
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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