Structure of PDB 1tmt Chain H Binding Site BS01

Receptor Information
>1tmt Chain H (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
>1tmt Chain L (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESY
Receptor-Ligand Complex Structure
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PDB1tmt Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		I16 D21 E23 M26 W29 D116 H119 P120 V121 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207
Binding residue
(residue number reindexed from 1)		I1 D6 E8 M11 W14 D113 H116 P117 V118 C119 Y134 K135 R137 N164 M211 K212 P214 N217 R218 W219
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1tmt, PDBe:1tmt, PDBj:1tmt
PDBsum1tmt
PubMed8251938
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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