Structure of PDB 1ths Chain H Binding Site BS01

Receptor Information
>1ths Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1ths Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		F34 R73 T74 R75 Y76
Binding residue
(residue number reindexed from 1)		F19 R68 T69 R70 Y71
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ths, PDBe:1ths, PDBj:1ths
PDBsum1ths
PubMed8376390
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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