Structure of PDB 1pzu Chain H Binding Site BS01

Receptor Information
>1pzu Chain H (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGY
MENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKV
LEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRV
HIPESSGRIVSLQTASNPIECSQELPMVERQDTDSCLVYGGQQMILTGQN
FTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRT
PVKVNFYVINGKRKRSQPQHFTYHPV
Ligand information
Receptor-Ligand Complex Structure
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PDB1pzu An asymmetric NFAT1 dimer on a pseudo-palindromic KB-like DNA site
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y424 T426 K520 R522 N523 R537 K538
Binding residue
(residue number reindexed from 1)		Y26 T28 K122 R124 N125 R139 K140
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1pzu, PDBe:1pzu, PDBj:1pzu
PDBsum1pzu
PubMed12949491
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

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