Structure of PDB 1nrp Chain H Binding Site BS01

Receptor Information
>1nrp Chain H (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
VGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDAC
EGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ
KVIDQFG
Ligand information
>1nrp Chain L (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DCGLRPLFEKKSLEDKTERELLESYIDGR
Receptor-Ligand Complex Structure
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PDB1nrp Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E23 I24 M26 W29 D116 H119 C122 Y134 K135 R137 N159 K202 N205 R206 W207
Binding residue
(residue number reindexed from 1)		E8 I9 M11 W14 D113 H116 C119 Y134 K135 R137 N163 K211 N216 R217 W218
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrp, PDBe:1nrp, PDBj:1nrp
PDBsum1nrp
PubMed8136362
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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