Structure of PDB 1hvu Chain H Binding Site BS01

Receptor Information

>1hvu Chain H (length=400) Species: 11676 (Human immunodeficiency virus 1)

IETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPEN
PYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKK
SVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWK
GSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEE
LRQHLLRHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVR
QLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIA
EIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITT
ESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWY

Ligand information

>1hvu Chain I (length=30)

agauuccguuuucagucgggaaaaacugaa

....((((..<<<<<.)))).....>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1hvu The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor.
• Resolution: 4.75 Å
• Binding residue (original residue number in PDB): K20 V21 K22 F416 V417
• Binding residue (residue number reindexed from 1): K16 V17 K18 F389 V390

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003964 RNA-directed DNA polymerase activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process

External links

• PDB: RCSB:1hvu, PDBe:1hvu, PDBj:1hvu
• PDBsum: 1hvu
• PubMed: 9687519
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)