Structure of PDB 1hut Chain H Binding Site BS01

Receptor Information
>1hut Chain H (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1hut The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		I24 H71 R75 Y76 E77 R77A I79
Binding residue
(residue number reindexed from 1)		I9 H66 R70 Y71 E72 R73 I75
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1hut, PDBe:1hut, PDBj:1hut
PDBsum1hut
PubMed8102368
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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