Structure of PDB 1hlt Chain H Binding Site BS01

Receptor Information
>1hlt Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
Q
Ligand information
>1hlt Chain L (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB1hlt Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E23 I24 G25 M26 W29 D116 H119 P120 C122 Y134 K135 R137 V157 N159 K202 P204 R206 W207
Binding residue
(residue number reindexed from 1)		E8 I9 G10 M11 W14 D113 H116 P117 C119 Y134 K135 R137 V157 N159 K207 P209 R213 W214
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1hlt, PDBe:1hlt, PDBj:1hlt
PDBsum1hlt
PubMed7947765
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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