Structure of PDB 1ghv Chain H Binding Site BS01

Receptor Information
>1ghv Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB1ghv A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		L65 R73 T74 R75 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		L60 R68 T69 R70 Y71 K77 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ghv, PDBe:1ghv, PDBj:1ghv
PDBsum1ghv
PubMed11292354
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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