Structure of PDB 1fph Chain H Binding Site BS01

Receptor Information
>1fph Chain H (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1fph The interaction of thrombin with fibrinogen. A structural basis for its specificity.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		F34 K36 L65 R73 T74 R75 Y76 R77A K149E
Binding residue
(residue number reindexed from 1)		F19 K21 L60 R68 T69 R70 Y71 R73 K154
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1fph, PDBe:1fph, PDBj:1fph
PDBsum1fph
PubMed1587268
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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